When it comes to neurorehabilitation, IRCCS Centro Neurolesi “Bonino di Pulejo” of Messina is one the most important reality in the country, boasting relevant technical resources that range from robotics to virtual reality. The center was established in 1992 by a university consortium - the result of an agreement between the University and the Foundation Bonino Pulejo. Five years later it was identified as Public Institution with legal status.
In 2006 the Health Ministry recognized it as Scientific Institute for Hospitalization and Care, turning it into a national reference point on the theme of rehabilitative Neuroscience for both healthcare and research activities.
Currently, it is the only center of this kind under public law in Sicily, carrying out its activity in traslational research for prevention, recovery and treatment of severe brain injuries acquired by annual and multiannual programmes.

Since 2016, due to the regrouping of the historic headquarters in Contrada Casazza and Ospedale Piemonte - a hospital located in the very centre of the city of Messina- the mission of the center additionally involves activities carried out in Emergency- Urgency, Rehabilitation, Technological Innovation, Protected Discharge, Tele-home Care and Telemedecine Services.

This reality takes place in a multidisciplinary context with a multimedial approach, with the aim of putting the patient first in order for him to return to normality and live actively instead of suffering because of disability.

Among the research studies carried out by “Bonino Pulejo”, special attention is given to Neurodegenerative Diseases. The most frequent ones include dementia, such as Alzheimer’s disease, some movement disorders, as for instance Parkinson’s disease, Parkinsonism, Huntington’s disease and dystonia, as well as other progressive diseases affecting young people, such as Multiple Sclerosis, and older people, i.e. Amyotrophic Lateral Sclerosis.